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Thursday, October 20, 2016
Beau Toskich, M.D.
Assistant Professor and Associate Fellowship Director of Vascular and Interventional Radiology
University of Florida College of Medicine
Topic: Angiosomal Ablation
Locoregional therapy for the treatment and palliation of both primary and metastatic liver malignancy has undergone exponential growth within the past decade as both therapeutic technologies and data continue to advance at an exciting pace. The indication and utilization of transarterial radioembolization has expanded to include neoadjuvant and definitive applications within management algorithms. Methodical interrogation of hepatic tumoral neovascularity and liver angiosomal manipulation has allowed for ablative radioembolization to generate early outcomes typically reserved for surgical resection but performed safely in the out-patient setting with negligible morbidity.
Sponsored by VetDC, Inc.
Friday October 21, 2016
Michael V. Knopp, M.D., PhD
Professor of Radiology and Novartis Chair of Imaging Research
Ohio State University
Topic: MR and PET imaging in Veterinary Oncology – Current Capabilities in Diagnosis and Therapy Response Assessment
MRI and PET have evolved to be essential imaging methodologies in human oncology, both for diagnosis and response assessment. The demonstration of feasibility and utility of these methodologies for veterinary oncology evolved slowly due to multiple challenges. This presentation will introduce current state of the art for veterinary oncology and demonstrate operational models that enable access for veterinary patients.
Today, substantial experience exists for the use of MRI and PET in veterinary oncology. The presentation will give an overview on best practices, real clinical experiences and current trends. Veterinary PET imaging has been especially burdened by the management of radiation exposure. Recent PET acquisition techniques, especially developed by our team, open up low and ultra-low PET imaging approaches leading to radically reduced radiation exposure levels which makes veterinary patient handling after PET imaging procedures more readily manageable.
Both imaging methodologies are available with a large variability of capabilities; the presentation will address which are essential for Veterinary Oncology applications and how quality assurance needs to be managed for response assessment.
With more than a decade of evolution to use MRI and PET in Veterinary Oncology, the capabilities are increasingly available and clinically useful for appropriate care management. While the focus will be on the clinical imaging aspects, special consideration for veterinary clinical trials will also be addressed.
Sponsored by Puppy Up
Saturday, October 22, 2015
William H. McBride, PhD, DSc
Professor of Radiation Oncology
Assistant Vice-Chancellor for Research
University of California, Los Angeles (UCLA)
Topic: The Biology behind Radiotherapy for Cancer: Past, Present, and Future
Radiation therapy (RT) for cancer has been around for a long time and has evolved as a treatment along with the development of new technologies for radiation delivery. The biological basis for conventional delivery of radiation in 1.8-2.0Gy daily dose fractions 5 times per week at a moderate dose rate was derived empirically. However, it was given credence by elucidation of the 4Rs of radiobiology related to the possible advantages of dose fractionation. The recent advent of IMRT, IGRT, SRS, SRT, SBRT, Cyberknife, Gammaknife, Tomotherapy, RapidArc, HDR brachytherapy, protons, etc, has however encouraged or forced the use of smaller margins, inhomogeneous fields, adaptive radiotherapy, dose painting, and of larger dose fractions with considerable variation in delivery time and dose rate. The biological consequences of many of these changes are essentially unknown, but the way RT is being delivered is changing rapidly. At the same time, RT is seen as being much more than a cytotoxic agent. Of considerable interest is that it can act as an immunological adjuvant. As a result it is being explored in combination with various immunotherapies, in particular immune checkpoint inhibitors. This lecture will deal evaluate some of the constraints on the use of RT in the current era and will discuss where RT may be going in future efforts to improve radiotherapeutic benefit.
Sponsored by Merial
Mathieu Spriet, DVM, MS
Associate Professor of Diagnostic Imaging
University of California, Davis
Topic: PET of the Equine Distal Limb: Initial Experiences and Future Promise
Recent technological advancements have made Positron Emission Tomography (PET) available for imaging the equine distal limb. The first PET scan of a horse was performed at UC Davis in the spring of 2015 using a high resolution portable PET scanner. This newly available imaging technology provides access to cross-sectional functional imaging of the most commonly imaged anatomic region of the horse. Initial data suggests that PET will yield valuable additional information when compared with other imaging techniques, in particular for the determination of the activity of both soft tissue and osseous lesions. PET also appears to be more sensitive than other imaging modalities in detecting early or occult osseous lesions.
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